ABSTRACT
Background: Mean platelet volume [MPV], platelet distribution width [PDW] and P-LCR [platelet large cell ratio] are known platelet volume indices [PVI]. Currently, the platelet volume indices [PVI] have emerged to determine its value as biomarker of liver fibrosis
Objectives: The present study determined the Platelet volume indices [PVI] as non invasive physiological marker of liver fibrosis in chronic hepatitis C patients
Study Design: Case control study
Study Settings: Department of Gastroenterology, ISRA University Hospital and Asian Institute of Medical Sciences [AIMS] Hyderabad from May- December 2014
Subjects and methods: A sample of 64 patients; 32 controls and 32 chronic hepatitis C cases were studied. Subjects were selected by non-probability [purposive] sampling as per inclusion and exclusion criteria. Roche Hitachi Hematolyzer was used for platelet count and platelet volume indices. Liver fibrosis was determined from liver biopsies by METAVIR Score. Data was analysed on Statistix 10.0 [USA] at 95% confidence interval [P<0.05]
Results: The PVI [MPV, PDW and P-LCR] and platelet count were raised in cases compared to controls [p<0.05]. PVI showed major differences for METAVIR SCORE F[0] -F[4] of liver fibrosis [p<0.05]. MPV, PDW and P-LCR showed positive correlation [r= 0.93, r= 0.80 and r= 0.75] with METAVIR [p <0.0001] respectively
Conclusion: The Platelet volume indices may be used as non-invasive physiological markers for liver fibrosis in chronic hepatitis C patients instead of invasive technique of liver biopsy
ABSTRACT
Objectives: The present study was conducted to estimate brain natriuretic peptide [BNP] in heart failure patients and its association with left ventricular ejection fraction [LVEF]
Study design: Case control study
Place and duration: Department of Medicine, Cardiology and Physiology, Isra University, Hyderabad from July 2014- Dec 2014
Subjects and methods: A sample of 60 subjects comprising of 30 normal controls [group I] and 30 diagnosed cases of heart failure [group II] were selected through non-probability purposive sampling as per inclusion and exclusion criteria. Blood samples were collected for the estimation of BNP. Left ventricular function was assessed by echocardiography. Data were analyzed on SPSS 21.0, Student's t-test and chi-square test were used for continuous and categorical variables respectively. Pearson's correlation was used for association of BNP and LVEF. P value
Result: Mean age [+/-SD] of controls and cases were 51.5+/-5.56 and 50.6+/-5.25 years respectively [p=0.91]. of 60 subjects; 46 [76.6%] were male and 14 [23.3%] were female. BNP in controls and cases was noted as 77.06+/-,24.02pg/ml and 17506.3 +/-13348 pg/ml respectively. BNP was significantly increased in heart failure patients and it showed inverse correlation with ejection fraction [r =-0.76, p=0.0001]
Conclusion: It is concluded that the BNP may be used an indicator of left ventricular function in settings where echocardiography facility is not available